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Intra-Operative Lymphatic Mapping and Sentinel Node Biopsy in Laryngeal Carcinoma: Preliminary Results

عنوان مقاله: Intra-Operative Lymphatic Mapping and Sentinel Node Biopsy in Laryngeal Carcinoma: Preliminary Results
شناسه ملی مقاله: JR_IJOTO-27-4_006
منتشر شده در در سال 1394
مشخصات نویسندگان مقاله:

Ehsan Khadivi - Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Maryam Daghighi - Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Kamran Khazani - Sinus and Surgical Endoscopic Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Vahid Reza Dabbagh Kakhki - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Leili Zarifmahmoudi - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Ramin Sadeghi - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

خلاصه مقاله:
Introduction: Sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.In the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer.   Materials and Methods: Patients with biopsy-proven squamous cell carcinoma of the larynx were included in the study. Two mCi/۰.۴ cc Tc-۹۹m-phytate in four aliquots was injected on the day of surgery, after induction of anesthesia, in the sub-mucosal peri-tumoral location using a suspension laryngoscopy. After waiting for ۱۰ minutes, a portable gamma probe was used to search for sentinel nodes. All patients underwent laryngectomy and modified radical bilateral neck dissection. All sentinel nodes and removed non-sentinel nodes were examined by hematoxylin and eosin (H&E) staining.   Results: Ten patients with laryngeal carcinoma were included. At least one sentinel node could be detected in five patients (bilateral nodes in four patients). One patient had pathologically involved sentinel and non-sentinel nodes (no false-negative cases).   Conclusion:  Sentinel node mapping in laryngeal carcinoma is technically feasible using an intra-operative radiotracer injection. In order to evaluate the relationship of T-stage and the laterality of the tumor with accuracy, larger studies are needed. 

کلمات کلیدی:
Laryngeal, Larynx, Radiotracer, Sentinel, SCC, Squamous cell carcinoma

صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1387108/