Study of risk factors associated with primary liver cancer (PLC)
- سال انتشار: 1400
- محل انتشار: پنجمین کنگره بین المللی سرطان
- کد COI اختصاصی: CANCERMED05_144
- زبان مقاله: انگلیسی
- تعداد مشاهده: 281
نویسندگان
Gerash Amir-al-Momenin medical and educational center, Gerash University of Medical Sciences, Gerash, Iran
Department of Biotechnology, School of Paramedical Sciences, Gerash Faculty of Medical Sciences, Gerash, Iran
School of Nursing, Gerash University of Medical Sciences, Gerash, Iran.
Gerash Amir-al-Momenin medical and educational center, Gerash University of Medical Sciences, Gerash, Iran
چکیده
Introduction: Liver cancer is the fifth most common cancer and the third leading cause of death in the world. Hepatocellular carcinoma (HCC) accounts for about ۹۰% of primary liver cancers. The aim of this study was to investigate the risk factors for primary liver cancer. Methods: In this systematic review study, a set of databases including Science Direct, Irandoc, web of science, Pubmed were searched using keywords including cancer, liver, risk factor, and their equivalent terms. Then, among the obtained articles, ۵۳ case-control studies and twelve cohort studies performed on human specimens were reviewed. Results: The results showed in addition to hepatitis B and C as two common causes of liver cancer, low levels of selenium, zinc, iron, copper, manganese and high levels of arsenic and cadmium in blood samples were important risk factors for liver cancer. Positive history of diseases such as alcoholic/non-alcoholic fatty liver, liver cirrhosis, acute hepatic porphyria, alpha ۱-antitrypsin deficiency, metabolic syndrome, pyogenic abscess, gallstones, high cholesterol, high level of inflammatory factors, CYP۲D۶ heterozygous gene, and BMI above ۳۰ was associated with an increased risk of liver cancer. Results also identified that variables such as alcohol overdose (≥۲۳ g per day), smoking, and high consumption of processed red meat associated with an increased risk of liver cancer. Conclusion: According to the evidence obtained from previous studies on risk factors associated with liver cancer, it should be noted that diagnosis, screening, and prevention of these factors can be useful in reducing and incidence of liver cancer.کلیدواژه ها
cancer, liver, risk factorمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.