Co-existence of mutations in myeloproliferative neoplasms and their clinical significance: a prognostic approach

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 257

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شناسه ملی سند علمی:

CANCERMED05_105

تاریخ نمایه سازی: 27 دی 1400

چکیده مقاله:

Introduction: Myeloproliferative neoplasms (MPNs) are a group of clonal hematopoietic stem cell disorders that may occur after one or more mutations in hematopoietic progenitor cells. In this study, we will review the co-existence of mutations (especially dual mutations) in MPNs and its effect on the prognosis of patients. Methods: To find relevant published papers, we systematically searched six major international indexing databases, namely PubMed/Medline, EmBase, Cochrane central, ISI web of science and Scopus from Feb. ۲۰۰۰ until Jan. ۲۰۲۰. We included the following keywords in the analyses: Myeloproliferative Disorders, Mutation, Co-existence of Mutations, Acute myeloid leukemia. Results: Co-existence of several mutations in MPNs is mainly associated with a poor prognosis compared with the uni-mutated MPN disorders. There are several effective factors such as sequence of mutations, incidence of mutations in one cell or different cells, mutation and MPN type. Conclusion: It seems that monitoring the status of mutations in MPNs and recognizing the co-existence of mutations (especially dual mutations) in order to determine prognosis and possibility of progression to acute form of leukemia can lead to the prediction of prognosis in MPN patients as well as establishment of better and more reliable therapeutic strategies for patients.

نویسندگان

Elham Homaei Hadad

Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Seyed Mohammad Sadegh Pezeshki

Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran- Department of Laboratory Sciences, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science

Saeid Shahrabi

Department of Biochemistry and Hematology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan

Amal Saki Maleki

Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Najmaldin Saki

Thalassemia & Hemoglobinopathy Research Center, Health research institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran