Opium and cigarette smoking are independently associated with Bladder Cancer: The findings of a matched Case - Control Study

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 115

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شناسه ملی سند علمی:

CANCERMED05_041

تاریخ نمایه سازی: 27 دی 1400

چکیده مقاله:

Introduction: While bladder cancer is the ninth most common cancer in the world, in some parts of Iran including Kerman province, is the most common cancer among men. This study aimed to determine risk factors of bladder cancer in Kerman province, Iran. Method: During February to July ۲۰۲۰, in this matched hospital-based case-control study, ۱۰۰ patients with bladder cancer and ۲۰۰ healthy individuals (matched in age and sex) were recruited. Socio-demographics status, occupational exposures, common diet, history of drug use and family history of cancer were collected using a structured questionnaire. Bivariable and multivariable logistic regression were applied and crude and adjusted odds ratios along with their ۹۵% confidence intervals were calculated. Data were analyzed using Stata version ۱۴ software. Results: Opium consumption, cigarette smoking and low level of income increased chance of bladder cancer. Compared to never use, use of opium up to ۱۸۰۰۰ Gram -year was associated with increased chance of bladder cancer (AOR: ۶; ۹۵% CI =۲.۳, ۱۵.۵). The chance was higher among those who used opium more than ۱۸۰۰۰ Gram - year (AOR: ۱۱.۳; ۹۵% CI =۲.۳, ۱۵.۵). In comparison with never smokers, chance of bladder cancer increased among those who smoked up to ۲۰ pack-year cigarette) (AOR: ۳.۴; ۹۵%CI= ۱.۳, ۸.۹) and those who smoke ≥ ۲۰ pack-year (AOR: ۱۵.۸; ۹۵% CI= ۵.۹, ۴۲.۴). Conclusions: The observed strong dose-response association between opium consumption, cigarette smoking and bladder cancer highlights the need for harm reduction programs especially in regions with high burden of disease.

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نویسندگان

Zahra Abdolahinia

HIV/STI Surveillance Research Center, and WHO Collaborating center for HIV surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Hamid Pakmanesh

Department of Urology, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Moghaddameh Mirzaee

Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Azam Bazrafshan

Kerman Population-based Cancer Registry (KPBCR), Deputy of Health, Kerman University of Medical Sciences, Kerman, Iran

Mehdi Shafiei Bafti

Head of communicable and non-communicable diseases department, Kerman University of Medical Sciences, Kerman, Iran

Armita Shahesmaeili

HIV/STI Surveillance Research Center, and WHO Collaborating center for HIV surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran