chHDAC۱۱ mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development
- سال انتشار: 1400
- محل انتشار: علوم اعصاب کاسپین، دوره: 8، شماره: 1
- کد COI اختصاصی: JR_CJNS-8-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 109
نویسندگان
International Pardis Unit, University of Guilan, Rasht, Iran.
International Pardis Unit, University of Guilan, Rasht, Iran.
Department of Biology, School of Sciences, University of Guilan, Rasht, Iran.
Department of Cultivation, Faculty of Agriculture, University of Guilan, Rasht, Iran.
Department of Biology, School of Sciences, University of Guilan, Rasht, Iran.
چکیده
Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC۱۱ gene to deacetylate histone core in neurons and their supportive cells in developing the vertebrate Central Nervous System (CNS). Objectives: This study investigates the HDAC۱۱ potential role in early chicken CNS development by studying its mRNA expression profile which may have unique means in studying human subjects. Materials & Methods: Chicken HDAC۱۱ RNAs were reverse transcribed to cDNAs, and the amount of chHDAC۱۱ transcripts was measured by ΔCT mean calculation using the real-time quantitative PCR method. One-way ANOVA and Duncan’s analysis (SigmaStat software version ۴.۰) were used to test the statistical significance of the results. The levels of significance were set at P≤۰.۰۵. Quantitative data are presented as Mean±SD. Results: The amount of HDAC۱۱ mRNAs gradually increases, at least ۲-۳ times, from as early as day ۱۴ (E۱۴/HH۴۰) of prenatal cortex formation to day P۰ (E۲۰=HH۴۵) and continue to increase to day ۴۰ in both cortical and hippocampal regions of the postnatal chicken brain during development (*P≤۰.۰۵). HDAC۱۱ mRNA is not only expressed in the postnatal cortex and hippocampi regions but also—for the first time—in the developing brain during the prenatal period. Conclusion: Our results show a possibly important role for the latest found HDAC۱۱ conserved gene in the development of vertebrates’ embryonic brain, which in turn may have a significant impact on understanding human brain development.کلیدواژه ها
Gene expression regulation, Developmental, Cerebral cortex, Brainاطلاعات بیشتر در مورد COI
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