Maryam Emadzadeh - Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Mostafa Parizadeh - Metabolic syndrome Research center, Mashhad University of Medical Sciences, Mashhad, Iran
Reza afarzadeh-Esfehani - Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Reza Sahebi - Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ramin Sadeghi - Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Gordon A. Ferns - Brighton & Sussex Medical School, Division of Medical Education, Brighton, UK

Background: Various fortification strategies have been proposed to account to treat or prevent vitamin D deficiency. There have been controversial reports regarding the effect of vitamin D fortification on the lipid profile. The aim of present review is the evaluation of administration of vitamin D fortified products on lipid profile.Methods: We used databases including PubMed/Medline, ISI Web of Knowledge, Science Direct, Scopus and Cochrane Library. All randomized controlled trials that have assessed the relationship between consumption of vitamin D fortified products and serum lipid profile were included until ۲۰۲۰. The relationship between fortification dose as well as duration of intervention and plasma lipid profiles evaluated in separate sub-groups.Results: Among serum lipids including total cholesterol(TC), triglyceride(TG), low density lipoprotein(LDL) and high density lipoprotein(HDL), fortification of vitamin D was reported to have a significant effect on reducing total cholesterol (pooled estimate: -۰.۰۸۹ mmol/L, ۹۵%CI: -۰.۱۳۴ to -۰.۰۴۴, p<۰.۰۰۱). Its effect on other lipid profiles were not significant.Conclusion: This meta-analysis demonstrated that vitamin D fortification could significantly reduce TC both in long and short term interventions and in different products. However this reduction, whilst statistically significant, may not be clinically important. The effect of fortification on other lipid profile components vary depending on dose and duration

vitamin D, fortification, lipid profile, cholesterol, triglyceride, low density lipoprotein, high density lipoprotein