Banafsheh Gorji - Department of Chemistry, College of Science, South Tehran Branch, Islamic Azad University, Tehran, Iran(Research Center for Modeling and Optimization in Science and Engineering, South Tehran Branch, IslamicAzad University, Tehran, Iran
Mohammad Reza Allahgholi Ghasri - Department of Chemistry, College of Science, Yadegar-e-Imam Khomeini (RAH) Shahre Rey Branch,Islamic Azad University, Tehran, Iran

DHPMs are important class of organic compounds in pharmaceutical industry. Synthesis methods of themhave often long time reactions and low yields. In this study, synthesis of DHPMs via three-component one-potcondensation by using TCCA/n-TiO۲ as new catalyst has been reported. At first, nanoparticles of TiO۲ wasapproved by x-ray diffraction (XRD) and transmission electron microscopy (TEM). Then TCCA has been fixedon n-TiO۲ (TCCA/n-TiO۲) as a heterogeneous catalyst. DHPMs were prepared by reaction of urea/thiourea(۱۴ mmol), ethyl acetoacetate (۱۰ mmol) and aromatic aldehyde derivatives (۱۰ mmol) in present of TCCA/n-TiO۲ (۰.۰۳ g) as catalyst. The products were characterized by comparison of their melting points andspectroscopic data (FT-IR, ۱H-NMR and ۱۳C-NMR) with those reported. The present catalyst offers severaladvantages such as reduction of waste and environmental pollutions, simple purification, short reaction timesand excellent yields.

Dihydropyrimidinone, Biginelli reaction, Trichloroisocyanuric acid/nano TiO۲, Green chemistry