Synthesis of silica nanocomposite MSN-polyMAA for oral d rug delivery

The d iscovery of highly or dered mesoporous silic a materials by scientists at the Mobil Corporation in ۱۹۹۲ was quic kly recognized as a breakthrough that could lead to a vari ety of important applications. The effect of surface charge and pH on the release of The synthesis conditions for ma king mesop orous silica the mesoporous materials, used as a drug c arrier. Naproxen, the well-known nonsteroidal a nti-inflamm atory drug ( NSAID) , was loaded into the pores of mesopor ous silica modified mod ified by org anic ۳-(chl oropropyl)-trimethoxy-silane, ۴-(dim ethyl amin o)pyridin groups and then surface polymerization by mon omer Methacrylic acid ( MAA) have been successfully prepared and have been used as drug-c ontrolled delivery system of naproxen. In ad dition , the naproxen release rate depended on the su rface modification with the specific organic groups. materials pH-responsive drug release beh avior in vitro studied in vitro release of naprox en into simulated gastric fluid (Ph= ۱.۲) and intestinal fluid (Ph=۷.۴) .

کلیدواژه ها:

Drug delivery ، Naproxen ، silica ، nanoco mposite.