Acidic Nanomagnet as a Green Catal yst for the Synthesi s ۱,۲,۴,۵-Tetrasubstituted I midazole

Imidazoles are th e core structures of many biological systemssuc h as histidine, histamine and biotin, an activecomponent in drug chemistry, pesticides [۱].In recent years, there are growing intere sts on the catalytic properties of transition metal nanoparticles because of their large surface area and a great ratio of atoms rem aining at the surface [۲]. Although many researchers have been done, there is still the paramo unt challenge for the wide application of transition metal as cataly sts in the industry, i.e. how to separate and recycle them nanoparticle completely from the products.Through out of o ur investigation, on one-pot multicomponent reaction, he rein we report a simple highly versatile and efficient synthesis of ۱,۲,۴,۵-tetrasubstituted im idazoles by four comp onent cycloc ondensation of ۱,۲-dicarbonyl compounds with analdehyde, primary amine, and a mmonium acetate, as a mmonia source using fu nctional nano Fe۳O۴(F e۳O۴- pr-SO۳H)as catalyst in ethanol at moderate temperature.

کلیدواژه ها:

Green Catalyst ، Easy work- up ، Nanomagnet ، Imidaz ole