Characteri zation of Cysteine C oated Ma gnetite Nanoparticles as MR I Co ntrast Ag ent

Ferrofluids containing magne tic nanoparticles, have potential applications in drug delivery, cance r therapy, magnetic resonance imaging (MRI) c ontrast enha ncement age nt, etc [۱-۴]. One of the fundamen al preconditions for m entioned m edical applications is high stability of synthe sized ferro fluid with time and environmental variations. Among va rious param eters affect this stability , surfactant layer density plays an i mportant role.Forma tion of a high density coating will prevent a gglomeratio n or sedimentation of solid phase. Besides, the nature an d compositi on of surfac tant is an im portant factor. Cysteine with three f unctional g roups have a certain bin ding affinity to metal at oms specially Fe atoms.In this work, a kind of stabilized ferrofluid based on magnetite nanoparticles (mean core and its coating size a bout ۲۵.۲ and ۱.۱ nm, respectively) was sy nthesized via coprecipitation method. Cysteine was used as surfacta nt due to it s proper c onjunction to the surface of magne tite nanoparticles. Coating density was measured using TEM and TGA results based on an ind irect appro ach. Synthesized ferrofluid was characterized using Transmission Ele ctron Microscope (TEM ), Thermogravimetry Analysis (TGA), Dynamic Light Scat tering (DLS ) and Fourie r transform infrared spectroscopy (FT-IR) techniques. MRI studies show tha t the synthe sized ferrofluid can used as a potential contrast enhancement agent especially for imagi ng lymphati c system.

کلیدواژه ها:

Mag netite ، nano particles ، Co-precipitatio n ، Cysteine ، MR imagi ng.