HSA-FCCP interaction: Aggregation behavior of HSA-FCCP complex

Protein is a vital chemical substance in our life and the predominant target of many drugs in the human body. Thus, investigate upon protein-drug interaction is very useful for determining the therapeutic effectiveness of drugs on bio targets. Human serum albumin (HSA) is the most important protein of the blood plasma that acts as a carrier for various drugs such as anti-cancer drugs [۱]. It has been proved that macromolecule such as albumin notably accumulates in tumor tissues so HSA is a potential drug carrier of anti-cancer agents such as FCCP [۲]. FCCP is a potent uncoupling agent that uncouples mitochondrial oxidation from phosphorylation, thus it can improve from energy production by mitochondria in cancer cells and cusses cell death [۳]. In this work we study on the interaction between HSA and FCCP and aggregation behavior of HSA in response to the existence of FCCP by resonance light scattering (RLS) and Zeta-potential measurements.

کلیدواژه ها:

HSA ، FCCP ، Zeta-potential ، RLS.