M Sohanian - Depar tment of Chem istry, Islamic Azad UniversityShahr-e Rey Branch, Tehr an, Iran
R Fazaeli - Modeling and Optimization Research Center in Science an d Engineering, Islamic Azad University-So uth Tehra n Branch, Teh ran, Iran
M Yousefi - Depar tment of Chem istry, Islamic Azad UniversityShahr-e Rey Branch, Tehr an, Iran

Oxali platin is one of the most successful a nticancer d rugs ever pr oduced .It is believed to work by bi nding to D NA leading to apoptosis. Since th e binding of Pt to D NA is kinetically controlled, a better understanding of th is process requires the use of q uantum chemical methods for probing transition states.

Anticancer, DNA , Platinum, Oxaliplatin