Computational st udy of aza-adaman tanes as multivalen t bases

Multi valent bases are a group of compou nds having high basic capacities [ ۱] appropriate for the interaction with biopolymers (proteins and DNA) at appropriate PH [۲]. So far, a nu mber of co mpounds have been used as multivalent bases for the trans fection of DNA to cyt oplast and c ell nucleus [۳]. In this report, we investigate properties of tetra-aza-ad amantane (T AA), hexa- aza-adamantane (HAA) and deca-aza-adamantane (DAA) proposed as the core of a class of more stable and manageable multivalen t bases.

کلیدواژه ها:

Azaa damantanes ، Protonation ، Multivalen t Base ، B۳L YP ، Isomerism