Correlation of a well-known genetic variation in one carbon metabolism pathway with breast cancer susceptibility in Iranian population

The one carbon metabolism pathway is an important cycle in the cellular reactions. One of a key gene in the mentioned pathway is methylenetetrahydrofolate reductase. This gene contains numerous variations that the rs۱۸۰۱۱۳۳ is considered as the most common polymorphism of this gene. This study aimed to examine the correlation of above-mentioned genetic variation with breast tumor risk in Iran by meta-analysis. In a systematic search, valid electronic databases such as PubMed and Goggle scholar were used to gain eligible studies. After search and screening procedure five suitable papers were included in our meta-analysis. To evaluate the strength of association values, the odds ratio (OR) and ۹۵% confidence interval (CI) were examined by http://bioinfo.genyo.es/metagenyo online software. The data from meta-analysis illustrated that the rs۱۸۰۱۱۳۳ genetic variation is correlated with breast cancer in TT vs. CC and TT vs. CC+CT hereditary models within Iranian women. Also, the pooled OR revealed that the studies with sample size> ۲۵۰ are associated with breast cancer. According to these finding the studied single nucleotide polymorphism could be considered as molecular genetic variation for breast cancer in Iranian women.

کلیدواژه ها:

Genetic variation ، risk factor ، One-carbon metabolism ، Iran