Buchholzia coriacea seed extract attenuates mercury-induced cerebral and cerebellar oxidative neurotoxicity via NO signaling and suppression of oxidative stress, adenosine deaminase and acetylcholinesterase activities in rats
محل انتشار: مجله گیاهان دارویی ابن سینا، دوره: 12، شماره: 1
سال انتشار: 1401
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 162
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شناسه ملی سند علمی:
JR_AJP-12-1_005
تاریخ نمایه سازی: 27 آذر 1400
چکیده مقاله:
Objective: Mercury (Hg) is a classic cumulative neurotoxicant implicated in neuronal deficit via oxidative damage and inflammatory responses. We sought to investigate whether Buccholzia coriacea seed methanol extract (BCSE) would modulate oxidative neurotoxicity induced by Hg in rats.Materials and Methods: Rats were orally treated with BCSE (۲۰۰ or ۴۰۰ mg/kg body weight of rat) for ۲۸ days, while Hg was administered from day ۱۵ to day ۲۸. After sacrifice, antioxidant enzyme activities, reduced glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA), and acetylcholinesterase (AchE) and adenine deaminase (ADA) activities were evaluated in the cerebrum and cerebellum of rats.Results: Mercury induced significant depressions in catalase (CAT) and glutathione peroxidase (GPx) activities and GSH levels, whereas levels of NO and activities of AchE and ADA markedly increased. The histopathology of the brain tissues confirmed these changes. In contrast, BCSE administration prominently modulated the brain NO production and reversed the Hg-induced biochemical alterations comparable to normal control.Conclusion: Methanol extract of B. coriacea seeds protects the cerebrum and cerebellum against Hg-induced brain damage via its antioxidant and NO modulatory actions.
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نویسندگان
Simeon Egba
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
Ademola Famurewa
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria
Lilian Omoruyi
Department of Biochemistry, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria