Characteristic features and surgical outcome in bisphosphonate-associated atypical femoral fracture: A retrospective observational study
- سال انتشار: 1400
- محل انتشار: مجله بین المللی پزشکی رضوی، دوره: 9، شماره: 4
- کد COI اختصاصی: JR_RIJO-9-4_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 244
نویسندگان
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
چکیده
Background: Bisphosphonate-associated atypical femoral fracture (AFF) is a rare and serious condition with poorly understood characteristics and management. Objectives: To evaluate the characteristic features and outcomes of AFF in a two-center cohort study.Methods: In a retrospective survey, medical profiles of ۲۲ AFF patients, who have used alendronate for > ۱۲ months, were reviewed. The demographic characteristics such as age, gender, and BMI, the clinical features including symptoms, symptom duration, radiologic characteristics including fracture site, the severity of the fracture, and contralateral involvement, surgical characteristics including the type of surgery union period and postoperative complications such as fixation failure, and union problems were extracted from the patients’ profiles.Results: The study population included ۴ males and ۱۸ females with a mean age of ۷۰.۶±۱۱.۹ years. The mechanism of fracture was falling down in ۲۱ (۹۵.۵% ) patients. The mean duration of bisphosphonate consumption was ۳.۸±۲ years. Prodromal symptoms (pain and limping) were recorded in ۱۲ (۵۴.۵۵%) patients. The fracture was in the femoral shaft in ۱۵ (۶۸.۲%) and in the subtrochanteric in ۷ (۳۱.۸%) patients. The fixation device was the intramedullary nail in ۱۸ (۸۱.۸%) and plate in ۴ (۱۸.۲%) patients. The mean union period was ۸.۳±۲.۸ months. Union complications (delayed or nonunion) occurred in ۶ (۲۷.۳%) patients. Fixation failed in ۵ (۲۲.۷%) patients (۳ nails and ۲ plate fixation).Conclusions: AFF is associated with a prolonged union. The intramedullary nail provides a more secure fixation. Prodromal symptoms could be used for earlier detection of patients. کلیدواژه ها
Atypical femoral fracture, bisphosphonate, alendronate, Surgery, outcome.اطلاعات بیشتر در مورد COI
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