Promising Effects of Vitex Agnus-Castus on Quality of Life and Sexual Function in Premenopausal Relapsing Remitting Multiple Sclerosis Patients

Background and aims:Current therapeutic regimens are not able to solve hormonal imbalance in young multiple sclerosis (MS) women and the clinical benefits of hormone therapy in MS patients remain controversial. This open labeled pilot study was aimed to find the role of Vitex agnus-castus plant supplement daily regimen in serum testosterone level , Expanded Disability Status Scale (EDSS), sexual function and overall quality of life in premenopausal MS patients.Methods: To achieve these goals, Molecular Docking on Vitex agnus-castus standard fruit extract constitutes performed and ۳۰ eligible patients were selected for the clinical part of this study. Patients received two Vitagnus® film tablets in addition to their drugs for ۹۰ days.Results: Some plant extract components showed strong affinity to Androgen Receptor Ligand binding domain. Significant reduction in EDSS (۱.۸۳۹ vs.۱.۶۴۳, p=۰.۰۰۳) and significant elevation in serum testosterone levels [۳۸۸.۶(±۰.۱۶۹۰۰) vs. ۴۶۸. (±۰.۱۸۱۴۴) ۲ng/dL (p=۰.۰۲۶)] were also observed at the completion of the intervention. Menstrual irregularities disappeared in all ۲۸ patients who completed this study. MSQL-۵۴ criteria at the completion of study (day ۹۱) showed lower stress levels, improved vitality/emotional health and normalized sexual activities without significant effect on sleep disorders and cognitive functions of patients. Vitex agnus-castus treatment by predictable AR LBD affinity improved the emotional state, sexual life, EDSS score and overall quality of life in premenopausal RRMS patients.Conclusion: Our results suggest Vitagnus® film tablet as safe and promising supplement with some benefits in MS women who are suffering from disease induced emotional and sexual impairments.

کلیدواژه ها:

multiple sclerosis ، Vitex agnus-castus ، Quality of Life ، Testosterone ، Molecular Docking