Regenerative Medicine and Female Fertility Perspective: A Systematic Review

Background: Female infertility is a global medical condition that can be caused by various disorders of the reproductive system, including premature ovarian failure (POF), polycystic ovary syndrome (PCOS), endometriosis, Asherman syndrome, and preeclampsia. This review aims to provide a brief overview of the current advances in the field of women reproductive health and systematically review the potential and understudy methods used there.Methods: Throughout this review, we systematically searched MEDLINE to identify ۱۶۷ articles related to female productive system. About ۳۲ articles have been chosen for systematic review after duplicate elimination and selection of eligible ones were included with criteria such as having a good statistical population or in vitro background and newer therapies or studies addressing key therapies and facing challenges in the field.Results: Novel regenerative medicine, consisting of tissue engineering, stem cell-based therapies or the development of advanced human cell-based in vitro-manufactured preclinical test systems offer the possibility to create laboratory-grown tissues to restore or establish normal organ function. Despite advancements in reproductive medicine and reconstructive surgery, there is an increased demand for the development of immune-compatible biological tissue substitutes when native healthy tissue is lacking, due methods such as organs on chip and microfluidic technologies raise to provide technical helps by providing powerful in vitro tools, allowing the simulations.Conclusion: Currently, there are no ideal treatments for severe IUA. Surgical release, hormone application or IUDs show their defects, respectively, such as failure in complete lysis and dosage control, and mismatch of IUD size. Regenerative medicine by tissue engineering offers plenty of alternative choices that may heal the wound and repair the injuries by structurally and biologically mimicking the native organ and environment.

کلیدواژه ها:

Reproductive organs ، Women health ، Regenerative medicine ، Tissue engineering ، Cell Scaffold ، Hydrogels