A case report of Vipoma with calcification of abdominal and prostate vessels

Background and Objective: Vasoactive intestinal peptides (VIPoma) are neuroendocrine tumors that involve ۱ in ۱۰ million people annually. Most VIPomas occur in the tail of the pancreas. The main symptoms are severe diarrhea causing hypokalemia, dehydration, hypochloremia and flushing. Symptoms of hypokalemia and dehydration are such as lethargy, nausea, vomiting, weakness and muscle cramps and in patients with dehydration, total calcium levels of blood increase. Diagnosis requires increased VIP serum levels and high volume diarrhea. Definitive diagnosis is done by CT/MRI and endoultrasonography. The most important primary measure in the treatment is the modification of dehydration, hypokalemia and water replacement and electrolytes. In these patients, long effect somatostatin analogues are selective treatments. In many cases VIPoma is associated with liver metastasis when diagnosed. The aim of this study was to introduce a new complication sample in VIPoma tumor that necessities more attention.Patient Report: A ۶۵-year-old man who referred to Imam Reza Hospital in Mashhad with complaint of watery diarrhea without blood excretion and weight loss from ۴ months ago. Routine tests were requested for him and the tests showed potassium loss, total protein and HDL along with increased levels of urea, sodium, CRP and hematocrit. Differential diagnoses included IBD, post small bowel resection, VIPoma and radiation enteritis and Abdominal and pelvic sonography requested. In echo sonography, the head and body of the pancreas were detected and due to the high serum level of intravenouspyelography (IVP), the final diagnosis of VIPoma was suggested.For more investigation, the patient underwent CT enterography that calcification plaques were seen in abdominal aorta, lower mesenteric and iliac with prostate calcification as a rare complication. Finally, this patient was treated with octreotide with a metastatic VIPoma diagnosis and after discharge, he was introduced to the oncologist for continued treatment. Conclusion: The result of this case study is the report of aortic calcification, mesenteric, iliac and prostate in a patient with VIPoma, which is an unexplained complication and considering the possibility of involvement of different organs, it is effective in improving the prognosis of the patient

کلیدواژه ها:

Vipoma ، Abdominal Vascular Calcification ، Prostate Calcification