Effects of curcumin on cognitive function scores in woman with premenstrual syndrome and dysmenorrhea: a triple -blind, placebo-controlled clinical trial
- سال انتشار: 1399
- محل انتشار: چهاردهمین کنگره پژوهشی سالیانه دانشجویان علوم پزشکی شرق کشور
- کد COI اختصاصی: MSEMSMED14_084
- زبان مقاله: انگلیسی
- تعداد مشاهده: 295
نویسندگان
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN۱ ۹PH, UK
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
چکیده
Dysmenorrhea and premenstrual syndrome (PMS) are common gynecological conditions. Many women suffering from PMS and dysmenorrhea also experience emotional, psychological and cognitive problems. This randomized, triple-blind, placebo-controlled trial was conducted to assess the effects of a curcumin supplementation on cognitive abilities. Methods: Women who suffered from both PMS and dysmenorrhea were enrolled, and were randomly assigned to receive curcumin (n = ۶۲), or placebo (n = ۶۲). Each subject received either a capsule containing ۵۰۰ mg of curcuminoid, or a placebo daily, for ۱۰ days (۷ days before and until ۳ days after onset of menstrual bleeding) over ۳ menstrual cycles. The Cognitive Abilities Questionnaire was used to measures cognitive functions in seven specific areas.Result: At baseline, there were no significant differences between the placebo and the curcumin groups, with respect to age, cardio-metabolic variables, cognitive abilities task scores and dietary intake (p> ۰.۰۵). Significant increments were found in scores of memory (۳.۵±۳.۱ vs. ۰.۴۰±۳.۸ in the curcuminoids and placebo groups, respectively; p=۰.۰۳۵), inhibitory control and selective attention (۳.۰۳±۳.۷ vs. ۰.۴۳±۳.۷; p= ۰.۰۲۷) and total cognitive abilities (۸.۳±۱۲.۳ vs. ۲.۲±۱۲.۴; p=۰.۰۲۵) after curcuminoids supplementation versus placebo group.Conclusion: Curcumin has a beneficial effect on cognitive function scores in women with PMS and dysmenorrhea, with improvements in memory, inhibitory control and selective attention.کلیدواژه ها
memory; cognition; turmeric; menstruationاطلاعات بیشتر در مورد COI
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