Evaluation of Serum Cortisol Levels and Response to Cosyntropin Test in Methadone-Treated Opium Addicts
- سال انتشار: 1399
- محل انتشار: چهاردهمین کنگره پژوهشی سالیانه دانشجویان علوم پزشکی شرق کشور
- کد COI اختصاصی: MSEMSMED14_083
- زبان مقاله: انگلیسی
- تعداد مشاهده: 163
نویسندگان
Birjand university of medical sciences, Birjand, Iran
Birjand university of medical sciences, Birjand, Iran
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
anesthesiology and critical care department, Birjand University of Medical Sciences, Birjand, Iran
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran
چکیده
Background and Objective: Opium has been used for thousands of years for medical and analgesic purposes and also its misuse has increased in recent years. Methadone, a synthetic opioid has been used as an analgesic and to help patients quit opium addiction. However, some evidence suggest long-term use of opioids can affect hypothalamic-pituitary-adrenal axis. To assess this hypothesis, we aimed to evaluate the serum cortisol level and response to cosyntropin stimulation test in opium addicts under methadone treatment.Materials and Methods: The study was conducted in November of ۲۰۱۹ in Imam Reza Hospital Rehab Center, Birjand, Iran. ۳۸ methadone-treated opium addicts participated in the study. Initially, ۵ cc of blood was taken, then, ۲۵۰ μg intramuscular cosyntropin was injected. After ۳۰ and ۶۰ minutes two other blood samples were obtained. These procedures were performed between ۸ to ۹ AM. The data were analyzed using SPSS.Findings: There was a significant difference between serum cortisol levels in methadone users (۹.۴۶ ± ۵.۴۲ µg / dl) and its normal values (=۱۴ µg / dl) (p < ۰.۰۰۱). The mean response to cosyntropin stimulation test in methadone users was ۹.۳۴± ۸.۱۱ µg / dl. ۵۵% of our participants had adrenal insufficiency. Conclusions: Serum cortisol level was significantly different in methadone-treated patients compared to normal values. Therefore, we recommend measuring serum cortisol level in long-term opioid users before major medical procedures to use stress doses of corticosteroids if needed.کلیدواژه ها
Adrenal insufficiency, Cortisol, Cosyntropin test, Methadone, opioidsاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.