Fatemeh Mirashrafi - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh Tavakolinejad - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Amin Amali - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Arezou Abasi - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Behrooz Amirzargar - Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction:The present study aimed to compare the effects of paracetamol and ibuprofen on pain, bleeding, nausea, and vomiting following adenotonsillectomy in children.Materials and Methods:This was a prospective, double-blinded, randomized clinical trial. Block randomization was used to assign ۵۰ patients to two groups of paracetamol and ibuprofen. In the paracetamol group, subjects received ۱۵ mg/kg oral paracetamol ۳۰ min before the induction of anesthesia, followed by the same dosage every ۶ h postoperatively. Meanwhile, the ibuprofen-treated group took ۱۰ mg/kg oral ibuprofen ۳۰ min before and every ۶ h after the operation. The subjects in both groups received the medication for three postoperative days. The postoperative pain score was assessed ۶ h after the surgery and during the second and the third postoperative days. Nausea and vomiting episodes were recorded in the first postoperative day and first postoperative week. Results:Based on the results, intraoperative and postoperative bleeding in both groups was not significantly different. The mean score of pain in the first postoperative day (۶ h after the surgery) and the second and the third postoperative days did not show any statistical difference. The ibuprofen group experienced fewer vomiting episodes, compared to the paracetamol group during the first postoperative day (P=۰.۰۱۱). Vomiting episodes in the first postoperative week did not illustrate any significant difference. Conclusion:As evidenced by the results of the current study, Ibuprofen had the same effect on the alleviation of postoperative pain, caused fewer vomiting episodes, and did not cause excessive bleeding as an NSAID. Therefore, Therefore, oral administration of ibuprofen is suggested for pain relief and management of other complications following adenotonsillectomy in children.

Adenotonsillectomy, Paracetamol, Ibuprofen