Mohammad Karami - Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Faezeh Karimian Nokabadi - Department of Toxicopharmacology, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Mohammad Ali Ebrahimzadeh - Department of Chemistry, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Farshad Naghshvar - Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

  Objective(s): Because of the high total phenolic contents of Feijoa sellowiana , its nephroprotective effect was determined in ۳,۴-methylene dioxymethamphetamine (MDMA) treated mice.   Materials and Methods: Animals received ۱۰, ۲۰ and ۴۰ mg/kg doses of aqueous or methanol extract of F. sellowiana leaves, intra-peritoneally. After one hour, an acute administration of MDMA (۲۰ mg/kg, IP) was injected. Nephroprotective effect was assayed by determination of serum creatinine, serum urea and kidney glutathione level. Histopathological study was also used.   Results   : Both extracts at ۴۰ mg/kg resulted in a significant reversal in the raised serum creatinine levels (P <۰.۰۵). Not statistically significant was observed in effect of two extracts (P>۰.۰۵). A decrease in urea/ creatinine ratio was observed following aqueous extract treatment. Methanolic extract showed higher activity in increasing kidney glutathione (P Conclusion:   F. sellowiana extract resulted in a markedly decrease in the nephrotoxicity of MDMA in mice.

Feijoa sellowiana, Kidney glutathione, MDMA, Nephrotoxicity