Comparison and Evaluation of Current Animal Models for Perineural Scar Formation in Rat
- سال انتشار: 1392
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 16، شماره: 7
- کد COI اختصاصی: JR_IJBMS-16-7_012
- زبان مقاله: انگلیسی
- تعداد مشاهده: 106
نویسندگان
Tissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran Iran
Tissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran Iran ۲ Research Center for Neural Repair, University of Tehran, Tehran, Ira
Tissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran Iran
Tissue Repair Lab, Institute of Biochemistry and Biophysics, University of Tehran, Tehran Iran
Research Center for Neural Repair, University of Tehran, Tehran, Iran.Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Orthopedics and Trauma Surgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Objective (s): Scar formation in injured peripheral nerve bed causes several consequences which impede the process of nerve regeneration. Several animal models are used for scar induction in preclinical studies which target prevention and/or suppression of perineural scar. This study evaluates the translational capacity of four of physical injury models to induce scar formation around the sciatic nerve of rat: laceration, crush, mince and burn. Materials and Methods: Functional (Toe out angle), macroscopic, and microscopic evaluations were performed weekly for four weeks and correlation of findings were analyzed. Result: While macroscopic and microscopic findings suggested a well-developed and adhesive fibrosis surrounding the sciatic nerve, functional assessment did not reveal any significant difference between control and experimental groups (P> ۰.۰۵). Conclusion: Our study suggests that none of the applied animal models reproduce all essential features of clinical perineural scar formation. Therefore, more studies are needed to develop optimal animal models for translating preclinical investigationsکلیدواژه ها
Scar Sciatic nerve Translational researchاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.