Production, Quality Control and Biological Evaluation of ۱۶۶Ho-PDTMP as a Possible Bone Palliation Agent

سال انتشار: 1392
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 16، شماره: 5
کد COI اختصاصی: JR_IJBMS-16-5_010
زبان مقاله: انگلیسی
تعداد مشاهده: 353

نویسندگان

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran ۲ Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

Amir Reza Jalilian

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran ۲ Faculty

Zohreh Naseri

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Hassan Yousefnia

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Ali Bahrami-Samani

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Mohammad Ghannadi-Maragheh

Radiopharmaceutical Research & Development Laboratory (RRDL), Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

Hossein Afarideh

Faculty of Energy Engineering and Physics, Amirkabir University of Technology, Tehran, Iran

چکیده

Objective(s):In this study, ۱۶۶Ho-۱,۲-propylene di-amino tetra(methy۱enephosphonicAcid) (۱۶۶Ho-PDTMP) complex was prepared as a bone palliation agent. Materials and Methods:The complex was successfully prepared using an in-house synthesized EDTMP ligand and ۱۶۶HoCl۳. Ho-۱۶۶ chloride was obtained by thermal neutron irradiation (۱ × ۱۰۱۳ n.cm-۲.s-۱) of natural Ho(NO۳)۳ samples followed by radiolabeling and stability studies. Biodistribution in wild type rats was also peformed. Results: The complex was prepared with thespecific activity of ۲۷۸ GBq/mg and high radiochemical purity (> ۹۹%, checked by ITLC). ۱۶۶Ho-PDTMP complex was stabilized in the final preparation and in the presence of human serum (> ۹۰%) up to ۷۲ hr. The biodistribution of ۱۶۶Ho-PDTMP in wild-type rats demonstrated significant bone uptake was up to ۴۸ hr compared to ۱۶۶HoCl۳. Conclusion: The produced ۱۶۶Ho-PDTMP properties suggest a possible new bone palliative therapeutic to overcome the metastatic bone pains.

کلیدواژه ها

Biodistribution ۱۶۶Ho PDTMP Radiopharmaceutical Therapy

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.