The Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats

  • سال انتشار: 1391
  • محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 15، شماره: 5
  • کد COI اختصاصی: JR_IJBMS-15-5_015
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 210
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نویسندگان

Zakieh keshavarzi

North Khorasan University of Medical Sciences, Bojnord, Iran

Mohammad Khaksari

Physiology Research Centre, Kerman University of Medical Sciences, Kerman, Iran

Zohre Razmi

Kerman University of Medical Sciences, Kerman, Iran

Ava Soltani Hekmat

Physiology Research Centre, Kerman University of Medical Sciences, Kerman, Iran

Vida Naderi

Kerman University of Medical Sciences, Kerman, Iran

Sima Rostami

Kerman University of Medical Sciences, Kerman, Iran

چکیده

Objective(s) Cytokines such as IL-۱β are involved in inflammatory responses. This study evaluated the role of two different kinds of drugs (ibuprofen and celecoxib) on brain IL-۱۰ and IL-۱β after traumatic brain injury (TBI) in male rats. Materials and Methods Rats were assigned into ۶ groups: intact, sham, TBI, and treated rats with vehicle, celecoxib or iboprophen. Cytokine concentrations were quantified by ELISA kits. Results Groups showed no significant difference in brain IL-۱۰ either after TBI induction or after treatment with ibuprofen or celecoxib. Serum IL-۱۰ in vehicle or ibuprofen treated animals was lower than in sham groups (P< ۰.۰۱). Brain IL-۱β decreased after treatment by ibuprofen or celecoxib (P< ۰.۰۰۱). There was no statistical difference in serum IL-۱β in TBI and intact. Serum IL-۱β significantly decreased in rats that received celecoxib compared to TBI group (P< ۰.۰۱). Conclusion Based on our study IL-۱β can decrease through both cyclooxygenase ۱ (COX-۱) and COX-۲ pathway but serum IL-۱β can decrease only by COX-۲ pathway.

کلیدواژه ها

Brain injury, Celecoxib, Ibuprofen, Interleukin-۱۰

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