Effect of Crocus sativus extracts and its active constituent safranal on the harmaline-induced tremor in mice
- سال انتشار: 1394
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 18، شماره: 5
- کد COI اختصاصی: JR_IJBMS-18-5_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 294
نویسندگان
Department of Pharmacology and Physiology, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran
Neuroscience Research center, Department of Toxicology and Pharmacology, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
Pharmaceutical Research center, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Due to unsatisfactory response or intolerable side effects of current drugs, treatment of essential tremor remains inadequate. Thus, we aimed to investigate the protective and therapeutic effects of aqueous and ethanolic extracts of Crocus sativus (saffron), and its active consistent, safranal, on the harmaline-induced tremor in mice. Materials and Methods: To induce tremor, harmaline (۳۰ mg/kg) was injected intraperitoneally. Test groups were also given the aqueous and ethanolic extracts of saffron (۴۰, ۸۰, and ۱۶۰ mg/kg) as well as safranal (۰.۱, ۰.۳, and ۰.۵ ml/kg), intraperitoneally, ۱۰ min before harmaline administration (prophylactic study) or ۱۰ min after the onset of tremors (curative study). The latency of onset, duration, and intensity of tremor were recorded. Results: The extracts (۸۰ and۱۶۰ mg/kg) dose dependently attenuated duration of harmaline-induced tremors as did reference drug, propranolol (۲ and ۵ mg/kg). Only the highest dose of extracts (۱۶۰ mg/kg) attenuated intensity of harmaline-induced tremors throughout the study. Safranal at the doses of (۰.۱ and ۰.۳ ml/kg) but not ۰.۵ ml/kg attenuated duration and intensity of tremor. Onset of tremor increased with the extracts (۸۰ and ۱۶۰ mg/kg) in prophylactic study, as the effect observed with propranolol at the dose of ۵ mg/kg. Safranal did not affect the latency of tremor. Conclusion: Both aqueous and ethanolic extracts of saffron and with a less effect, low doses of safranal, have relatively protective and suppressive effects on the harmaline-induced tremor and different constituents of extracts seem to participate in the protective effects against harmaline induced tremor.کلیدواژه ها
Crocus sativus, Essential tremor, Harmaline, Safranalاطلاعات بیشتر در مورد COI
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