Protective Effect of Diosgenin and Exercise Training on Biochemical and ECG Alteration in Isoproterenol- Induced Myocardial Infarction in Rats
- سال انتشار: 1390
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 14، شماره: 3
- کد COI اختصاصی: JR_IJBMS-14-3_010
- زبان مقاله: انگلیسی
- تعداد مشاهده: 283
نویسندگان
Department of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
Department of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
Department of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
Department of Physiology, Drug Applied Research Center, Tabriz University of Medical Sciences,Tabriz, Iran
چکیده
Objective(s) Several studies have reported improved response of exercised hearts to myocardial infarction (MI). This study was aimed to evaluate the preventive role of treadmill exercise and diosgenin on cardiac marker enzymes, thiobarbituric acid reactive substances (TBARS), total antioxidant status (TAS), lipids, and electrocardiographic (ECG) patterns in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Materials and Methods One hundred Wistar rats were divided into ten groups: Control rats (C), saline (S), L-cremephor (LC), exercise (E), diosgenin dissolved in L-cremephor (۱۵ mg/kg/day) (D), exercise+ diosgenin (E+D), ISO injected (۱۵۰ mg/kg) (ISO), exercise + ISO (E+ISO), diosgenin + ISO (D+ISO) and exercise+ diosgenin+ ISO (E+D+ISO). At the end of the experiment all animals anesthetized and blood samples were collected for biochemical estimation and also the ECG patterns were recorded. Results Exercise and diosgenin pretreatment significantly decreased the lactate dehydrogenase (LDH) and TBARS level in ISO injected animals. Exercise and diosgenin pretreatment significantly decreased serum total cholesterol and increased high density lipoprotein (HDL-C). ISO-treated rats showed pathological Q waves along with elevated ST segments. The altered electrocardiograms (ECG) of ISO-treated rats were also restored to near normal by diosgenin and exercise, but exercise and diosgenin had synergistic effects. Conclusion The present investigation demonstrates that combination of diosgenin and exercise exhibited significant protection against ISO induced electrocardiographical and biochemical changes. The cadioprotective mechanism(s) appear to be through changing lipid metabolism.کلیدواژه ها
Diosgenin, Isoproterenol, Myocardial infarction, Treadmillاطلاعات بیشتر در مورد COI
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