Relaxatory Effect of Gamma-Aminobutyric Acid (GABA) is Mediated by Same Pathway in Diabetic and Normal Rat Mesenteric Bed vessel

  • سال انتشار: 1390
  • محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 14، شماره: 1
  • کد COI اختصاصی: JR_IJBMS-14-1_013
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 188
دانلود فایل این مقاله

نویسندگان

Leila Farsi

Department of Basic Sciences, Gonabad University of Medical Sciences, Gonabad, Iran

Mansoor Keshavarz

Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Nepton Soltani

Department of Physiology, School of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

چکیده

Objective(s) Diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of endothelium in GABAinduced vasorelaxation. Materials and Methods After Diabetes induction,. Mesenteric arteries of animals were perfused. Vascular beds were constrictedwith phenylephrine. GABA (۱ to ۵۰ μM) was added into the medium and perfusion pressure was then recorded. Results In all groups of animals, relaxant response to GABA in mesenteric bed appeared. Although diabetes induction did not change mesenteric bed response to GABA, denuded vessels showed a reduced response to GABA both in control and diabetic animals. Conclusion GABA can induce endothelium dependent vasorelaxation in mesenteric vessels in normal and diabetic rats.

کلیدواژه ها

Diabetes, Endothelium, GABA, Mesenteric arteries, Rat

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.