Antioxidant Effects of Methanol Extract of Dracocephalum kotschyi in Acetic Acid Induced Rat Colitis Model
- سال انتشار: 1400
- محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 30، شماره: 138
- کد COI اختصاصی: JR_ZUMS-30-13838_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 344
نویسندگان
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
Dept. of Physiology and Pharmacology, North Khorasan University of Medical Sciences, Bojnurd, Iran
Dept. of Molecular and Cellular Biology, Faculty of Basic Science, University of Mazandaran, Mazandaran, Iran
Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
Poursina Hakim Digestive Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Original Articles - Clinical medicine (Article Number: e۵۶۸۲۱) Background and Objective: There is a worldwide trend towards substitute synthetic antioxidants with natural alternatives to treat inflammatory bowel disease (IBD) such as ulcerative colitis (UC). This study was conducted to evaluate the effects of Dracocephalum kotschyi extract on tissue injury and oxidative stress in an acetic-acid induced colitis model. Materials and Methods: ۴۸ male Wistar rats were allocated to ۶ groups: healthy control, colitis control, and ۴ treatment groups which administrated ۱۰, ۲۵, and ۵۰ mg/kg of D. kotschyi extract respectively, and ۲۰۰ mg/kg sulfasalazine once daily for ۸ days after colitis induced. Colitis severity was assessed using histologic and macroscopic changes of damaged colon, and enzymatic antioxidant activities like superoxide dismutase (SOD), total thiol (–SH), superoxide dismutase (SOD), and lipid peroxidation marker MDA (malondialdehyde) were evaluated. Results: D. kotschyi extract (۵۰mg/kg) decreased colonic macroscopic and histological damage scores, which were accompanied by a significant decrease in lipid peroxidation, and an increase in colonic antioxidant markers. Conclusion: The results suggest that D. kotschyi extract is effective against oxidative bowel damages induced in IBD and its beneficial effect is, at least in part, due to its antioxidant properties.کلیدواژه ها
Colitis, Oxidative stress, Herbal medicine, Inflammatory bowel diseaseاطلاعات بیشتر در مورد COI
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