Possible Involvement of Glutamatergic, Adrenergic and Dopaminergic System in Methylphenidate - induced Motor Activity and Mood-related Alterations in Rats
- سال انتشار: 1400
- محل انتشار: مجله علمی پژوهشی دانشگاه علوم پزشکی زنجان، دوره: 29، شماره: 137
- کد COI اختصاصی: JR_ZUMS-29-137_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 226
نویسندگان
Dept. of Medicine, Qom Branch, Islamic Azad University, Qom, Iran
Dept. of Physiology, Jinnah Medical & Dental College, Sohail University, Karachi, Pakistan
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
Dept. of Medicine, Qom Branch, Islamic Azad University, Qom, Iran
چکیده
Background and Objective: Methylphenidate (MPH), as a central nervous system stimulant, is often used to manage hyperactive disorders. The literature is scarce regarding the behavioral consequences of chronic MPH treatment and the role of involved receptors. Thus, in the current study involved receptors in MPH induced-anxiety, depression and motor activity disorders were evaluated. Materials and Methods: Seventy rats were randomly distributed to seven groups (n = ۱۰, per group); they were treated with normal saline, Domoic acid (DOM) (as AMPA/kainite receptor agonist), Bicuculline (BIC) (as GABAA receptor antagonist), Ketamine (KET) (as NMDA receptor antagonist ), Yohimbine (YOH) (as Alpha-۲ adrenergic receptor antagonist), or Haloperidole (HAL) (as D۲ dopamine receptor antagonist), simultaneously with MPH (۱۰ mg/kg). On days ۱۱, ۱۷ and ۲۴, some standard behavior tests including Elevated Plus Maze (EPM), Forced Swim Test (FST) and Open Field Test (OFT) were used to investigate anxiety, depression and motor activity disturbances, respectively. Results: Our study indicated that pretreatment of rats with KET, HAL and YOH abolished MPH induced - mood and motor activity disturbances. Conclusion: MPH by interacting with Dopaminergic, NMDA and ɑ۲-adrenergic receptors induces anxiety, depression and motor activity disorders.کلیدواژه ها
Methylphenidate, Aanxiety, Depression and Motor activity.اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.