Swimming exercise attenuates psychological dependence and voluntary methamphetamine consumption in methamphet- amine withdrawn rats
- سال انتشار: 1395
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 19، شماره: 6
- کد COI اختصاصی: JR_IJBMS-19-6_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 372
نویسندگان
Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran
Faculty of Educational Sciences and Psychology, Ferdowsi University of Mashhad, Mashhad, Iran
Laboratory of Animal Addiction Models, Research Center and Department of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
Faculty of Psychology and Educational Sciences, University of Semnan, Semnan, Iran
چکیده
Objective(s): This study evaluated the effect of swimming exercise during spontaneous methamphetamine (METH) withdrawal on the anxiety, depression, obsessive-compulsive disorder (OCD) and voluntary METH consumption in METH-dependent rats. Materials and Methods: Male Wistar rats were repeatedly administered with bi-daily doses of METH (۲ mg/kg, subcutaneous) over a period of ۱۴ days. Exercised rats were submitted to swimming sessions (۴۵ min/day, five days per week, for ۱۴ days) during spontaneous METH-withdrawal. Then, all animals were tested for the assessment of anxiety by using the elevated plus-maze (EPM), the grooming behaviors (OCD), and depression using forced swimming test (FST) and voluntary METH consumption using a two-bottle choice (TBC) paradigm for the assessment of craving. Results: The results showed that the swimmer METH-withdrawn rats exhibited an increase in EPM open arm time and entries and a reduction of immobility and grooming behaviors compared with the sedentary METH groups. Also, voluntary METH consumption was less in the swimmer METH-withdrawn rats than the sedentary METH groups throughout ۵–۸ days. Conclusion: This study showed that regular swimming exercise reduced voluntary METH consumption in animal models of craving by reducing anxiety, OCD, and depression in the METH-withdrawn rats. Thus, physical training may be ameliorating some of the withdrawal behavioral consequences of METH.کلیدواژه ها
Anxiety,, Craving,, Depression Methamphetamine- abstinance,, Obsessive-compulsive disorder,, Swimmingاطلاعات بیشتر در مورد COI
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