Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats
- سال انتشار: 1396
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 20، شماره: 1
- کد COI اختصاصی: JR_IJBMS-20-1_003
- زبان مقاله: انگلیسی
- تعداد مشاهده: 128
نویسندگان
Federal University of Mato Grosso (UFMT), Mato Grosso, Brazil
Federal University of Mato Grosso (UFMT), Mato Grosso, Brazil
University Center of Araxá (UNIARAXA), Minas Gerais, Brazil
University Center of Araxá (UNIARAXA), Minas Gerais, Brazil
São Paulo State University (UNESP), São Paulo, Brazil
Federal University of Mato Grosso (UFMT), Mato Grosso, Brazil
چکیده
Objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: Fifty male Wistar rats (۳۶-۴۰ weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn superoxide dismutase (Cu,Zn-SOD), and superoxide release by spleen macrophages were evaluated. For memory testing, adaptation and walking in an open field platform was used. GH-treated animals demonstrated better performance in exploratory and spatial open-field tests. Results: The latency time in both GH-treated groups was significantly lower compared with the latency time of the control groups. The diurnal GH treatment did not stimulate superoxide release but increased the CuZn-SOD enzyme levels. The nocturnal GH treatment did not influence the superoxide release and CuZn-SOD concentration. GH treatment also resulted in heart atrophy and lung hypertrophy. Conclusion: Growth hormone treatment improved the performance of executive functions at the cost of oxidative stress triggering, and this effect was dependent on the circadian period of hormone administration. However, GH treatment caused damaging effects such as lung hypertrophy and heart atrophy.کلیدواژه ها
Chronopharmacology, Executive function, Growth hormone, Superoxide anion, Superoxide Dismutaseاطلاعات بیشتر در مورد COI
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