Histopathological study of erythropoietin protective effect on carbon monoxide-induced cardiotoxicity in rat
- سال انتشار: 1396
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 20، شماره: 11
- کد COI اختصاصی: JR_IJBMS-20-11_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 166
نویسندگان
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University
Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Ahl Al Bayt, Karbala, Iraq
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University
Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Immunobiochemistry Laboratory, Immunology Research Center, Bu-Ali research Institute, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pathology, School of Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Electron Microscope Unit, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran
Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Objective(s): Cardiotoxicity is one of the major consequences in carbon monoxide poisoning. Following our previous work, in this study we aimed to define the myocardium changes induced by carbon monoxide (CO) intoxication and evaluate erythropoietin (EPO) effect on CO cardiotoxicity in rat. Materials and Methods: Severe carbon monoxide toxicity induced by ۳۰۰۰ ppm CO in Wistar rat. EPO was administrated (۵۰۰۰ IU/Kg, intraperitoneal injection) at the end of CO exposure and then the animals were re-oxygenated with the ambient air. Subsequently heart was removed and assessed by histopathology and electron microscopy examinations. Results: ۳۰۰۰ ppm CO induced significant myocardium injury; multiple foci of necrosis and lymphocyte infiltration compare with the control (P˂۰.۰۵). Electron microscopy examination showed myofibril lysis and mitochondrial swelling in myocardium due to ۳۰۰۰ ppm CO poisoning. However EPO administration after CO exposure resulted in significant reduction in cardiomyocytes injury (P˂۰.۰۵). Conclusion: Our results represented protective effect of EPO on cardiac injury induced by CO intoxication in rat.کلیدواژه ها
Carbon monoxide Poisoning, Cardiotoxicity, Erythropoietin, Histopathology, Ratاطلاعات بیشتر در مورد COI
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