Mechanisms of spinal cord injury regeneration in zebrafish: a systematic review
- سال انتشار: 1396
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 20، شماره: 12
- کد COI اختصاصی: JR_IJBMS-20-12_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 156
نویسندگان
Medical Student, Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran
Medical Student, Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran
Iran University of Medical Sciences, Sina Trauma and Surgery Research Center, Tehran, Iran
Tabriz University of Medical Sciences, Tabriz, Iran
Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, ۱۱۳۶۵-۳۸۷۶, Iran
چکیده
Objective(s):To determine the molecular and cellular mechanisms of spinal cord regeneration in zebrafish. Materials and Methods: Medical databases of PubMed and Scopus were searched with following key words: Zebrafish; spinal cord injuries; regeneration; recovery of function. The map of mechanisms was performed using Xmind software. Results: Wnt/ß-catenin signaling, L۱.۱, L۱.۲, Major vault protein (MVP), contactin-۲ and High mobility group box۱ (HMGB۱) had positive promoting effects on axonal re-growth while Ptena had an inhibitory effect. Neurogenesis is stimulated by Wnt/ß-catenin signaling as well as HMGB۱, but inhibited by Notch signaling. Glial cells proliferate in response to fibroblast growth factor (fgf) signaling and Lysophosphatidic acid (LPA). Furthermore, fgf signaling pathway causes glia bridge formation in favor of axonal regeneration. LPA and HMGB۱ in acute phase stimulate inflammatory responses around injury and suppress regeneration. LPA also induces microglia activation and neuronal death in addition to glia cell proliferation, but prevents neurite sprouting. Conclusion: This study provides a comprehensive review of the known molecules and mechanisms in the current literature involved in the spinal cord injury (SCI) regeneration in zebrafish, in a time course manner. A better understanding of the whole determining mechanisms for the SCI regeneration should be considered as a main goal for future studies.کلیدواژه ها
Regeneration recovery of function, Spinal cord regeneration, Spinal cord injuries, Zebrafishاطلاعات بیشتر در مورد COI
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