Moderate aerobic exercise training decreases middle-aged induced pathologic cardiac hypertrophy by improving Klotho expression, MAPK signaling pathway and oxidative stress status in Wistar rats
- سال انتشار: 1397
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 21، شماره: 9
- کد COI اختصاصی: JR_IJBMS-21-9_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 246
نویسندگان
Department of Physical Education and Sport Science, Jolfa Branch, Islamic Azad University, Jolfa, Iran
Department of Physical Education and Sport Science, Jolfa Branch, Islamic Azad University, Jolfa, Iran
Department of Physical Education and Sport Science, University of Mohaghegh Ardabili, Ardabil, Iran
Department of Kinesiology, College of Agriculture, Health and Natural Resources, University of Connecticut, Connecticut, USA
چکیده
Objective(s): This study aimed to investigate the effect of aerobic training on serum levels of Klotho, cardiac tissue levels of H۲O۲ and phosphorylation of ERK۱/۲ and P۳۸ as well as left ventricular internal diameter (LVID), the left ventricle wall thickness (LVWT) and fibrosis in middle-aged rats. Materials and Methods: Forty wistar rats, including young rats (n=۱۰, ۴ month-old) and middle-aged rats (n=۳۰, ۱۳-۱۵ months-old) were enrolled in this experimental study. The all young and ۱۰ middle-aged rats were sacrificed (randomly) under deep anesthesia without any exercise training as normal young control and normal middle-aged control respectively. The remaining ۲۰ middle-aged rats participated in ۴ (n=۱۰) or ۸-week (n=۱۰) aerobic exercise training. Results: There were significant differences in the plasmatic Klotho levels and the heart tissue levels of phosphorylated-ERK۱/۲ (p-ERK۱/۲), P-P۳۸ and H۲O۲, LVWT, LVID and fibrosis between young and middle-aged rats (P=۰.۰۱). Plasmatic Klotho level was significantly increased after eight weeks training (P=۰.۰۱۱). Also, p-ERK۱/۲ was significantly decreased after eight weeks and p-P۳۸ was significantly decreased in the fourth (P=۰.۰۱) and eight weeks of training (P=۰.۰۱). A similar decrease was reported for aging-induced H۲O۲ in the fourth (P=۰.۰۱۶) and eighth weeks (P=۰.۰۰۱). LVID was significantly increased in eight weeks, but LVWT and fibrosis was significantly reduced in the eighth week (P=۰.۰۱۱, P=۰.۰۲۸, P=۰.۰۰۱ respectively).Conclusion: Moderate aerobic training attenuates aging-induced pathological cardiac hypertrophy at least partially by restoring the Klotho levels, attenuating oxidative stress, and reduction in the phosphorylation of ERK۱/۲, P۳۸ and fibrosis.کلیدواژه ها
Exercise, Fibrosis, H۲O۲, Left ventricular hypertrophy, Klotho, Mitogen-activated protein, kinaseاطلاعات بیشتر در مورد COI
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