Plasmid-borne mobile colistin resistance (mcr-۱) in healthy humans and poultry in Iran
- سال انتشار: 1400
- محل انتشار: دومین کنفرانس بین المللی مطالعات میان رشته ای علوم بهداشتی، روانشناسی، مدیریت و علوم تربیتی
- کد COI اختصاصی: HPMECONF02_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 270
نویسندگان
Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, IranLiver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
Department of Animal Sciences, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran
Department of Microbiology, Institute Pasteur of Iran, Tehran, Iran
چکیده
Abstract Background and aim: The emergence of antimicrobial resistant bacteria has become a menace to global public health and socio-economic development. Colistin is used as the last resort antibiotic in refractory infections. However, resistant isolates are reported frequently. The aim of this study was to find mcr genes in healthy people poultry farms in Sanandaj, west of Iran. Methods and materials: In this study, fecal samples were collected from two groups of humans and poultry. Colistin containing screening media as well as colistin-EDTA containing medium to screen plasmid-mediated colistin resistance. PCR for prevalent mcr genes were performed. Antimicrobial susceptibility testing was done for mcr-harboring isolates. Results: In this study, no colistin-resistant bacteria were isolated from poultry samples (۰%) while two human E. coli isolates showed resistance to colistin (۰.۵۹%). Of which, one isolate was inhibited by EDTA and harbored mcr-۱ variant. The MIC for colistin was ۱۶ mg/L. Conclusion: The results indicated the low prevalence of this gene in healthy individuals and poultry industry. To the best of our knowledge, this is the first report of mcr in healthy individuals from Iran.کلیدواژه ها
mcr-۱, colistin, poultry, Escherichia coliاطلاعات بیشتر در مورد COI
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