Maternal aerobic running during mid or late gestation improves the quality of oogenesis and folliculogenesis in the ovary of neonatal rats: An experimental study
- سال انتشار: 1400
- محل انتشار: مجله طب تولید مثل ایران، دوره: 19، شماره: 9
- کد COI اختصاصی: JR_IJRM-19-9_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 297
نویسندگان
Abnormal Uterine Bleeding Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Department of Anatomy, Medicine Faculty, Semnan University of Medical Science, Semnan, Iran.
Department of Anatomy, Medicine Faculty, Semnan University of Medical Science, Semnan, Iran. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Department of Pathology, Semnan University of Medical Sciences, Semnan, Iran.
Department of Anatomy, Medicine Faculty, Semnan University of Medical Science, Semnan, Iran. Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Semnan, Iran.
چکیده
Background: Regular maternal exercise in pregnancy enhances the physiological, metabolic, and psychological health of mother and fetus. Objective: To determine the effect of maternal aerobic running during mid or late gestation on plasma levels of estrogen and progesterone and the histological alterations in the ovary of neonatal rats. Materials and Methods: Twenty-one female Wistar rats were randomly divided into experimental groups to exercises during the ۲nd or ۳rd wk of pregnancy (n = ۱۴) and a control group (n = ۷). After birth, the neonatechr('۳۹')s blood was obtained and the estrogen and progesterone levels were evaluated. The ovaries were then removed and used for histological investigations and apoptic assessment. Results: Higher concentrations of estrogen and progesterone were found in the neonates of the experimental groups (p = ۰.۰۰۱) compared to the control group. The experimental groups had a large ovarian diameter (۲nd wk: p = ۰.۰۴۴; ۳rd wk: p = ۰.۰۰۵) and angiogenesis (۲nd wk: p = ۰.۰۰۳; ۳rd wk: p = ۰.۰۰۱). In addition, significant enhancements were seen in the the experimental groups in terms of the number (۲nd wk: p = ۰.۰۱۷; p = ۰.۰۳۵) and diameter (۲nd wk: p = ۰.۰۴۶; ۳rd wk: p = ۰.۰۰۴) of primordial follicles, as well as in the diameter of primary oocytes (۲nd wk: p = ۰.۰۷۳; ۳rd wk: p = ۰.۰۱۹) compared to the control group. Moreover, rats that exercised had a lower number of apoptotic primordial follicles than the control group (۲nd wk: p = ۰.۰۰۱; ۳rd wk: p = ۰.۰۰۱). Conclusion: It was shown that maternal aerobic running can lead to increased plasma levels of estrogen and progesterone, also improved histological characteristics of the ovary in neonatal rats.کلیدواژه ها
Apoptosis, Exercise, Neonatal, Oogenesis, Ovary, Rat., آپوپتوز, ورزش, نوزاد, اووژنزیس, تخمدان, رت.اطلاعات بیشتر در مورد COI
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