Atorvastatin modulates the expression of aging-related genes in the brain of aging induced by D-galactose in mice
محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 24، شماره: 10
سال انتشار: 1400
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 207
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شناسه ملی سند علمی:
JR_IJBMS-24-10_009
تاریخ نمایه سازی: 11 مهر 1400
چکیده مقاله:
Objective(s): Atorvastatin (AT), a competitive inhibitor of ۳-hydroxymethyl-۳-glutaryl-coenzyme-A reductase, is a cholesterol-lowering drug. AT has been shown to have neuroprotective, antioxidant, and anti-inflammatory properties. Previously, we have reported that AT could attenuate the behavioral, renal, and hepatic manifestations of aging. To clarify further the mechanisms involved, the present study was designed to evaluate the effect of AT on the expression of some aging-related genes in the brain of aging mice induced by D-galactose (DG).Materials and Methods: For this purpose, AT (۰.۱ and ۱ mg/kg/p.o.) was administrated daily in DG-received (۵۰۰ mg/kg/p.o.) mice model of aging for six weeks. At the end of the experiment, mice were decapitated to remove the brains. Then, the expression profiles of sirtuin ۱ (Sirt۱), P۵۳, P۲۱, Bcl-۲, Bax, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), interleukin ۱ beta (IL۱β), tumor necrosis factor-alpha (TNFα), inducible nitric oxide synthase (iNOS), cyclooxygenase-۲ (COX-۲), and brain-derived neurotrophic factor (BDNF) were assessed using the real-time PCR method. Results: The present study shows that DG decreases the expression of Sirt۱, Bcl-۲, CAT, GPx, and BDNF while increasing the expression of P۵۳, P۲۱, Bax, IL-۱β, iNOS, COX-۲, and TNF-α. According to the findings of the present study, AT (more potentially at the dose of ۱ mg/kg) modulates the expression of these aging-related genes in the brain of aging mice. Conclusion: The results of the present study confirmed our previous reports on the anti-aging effects of AT at the gene level, the precise mechanisms and underlying pathways need further studies.
کلیدواژه ها:
نویسندگان
Manijeh Motevalian
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
Neda Tekyemaroof
Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
Mohammad Hadi Nematollahi
Department of Clinical Biochemistry, Kerman University of Medical Sciences, Kerman, Iran
Fatemeh Khajehasani
Department of Radiology, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Iman Fatemi
Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
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