Arezou Mahdavinejad - Toxicology Research Center, Department of Clinical Toxicology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Peyman Erfan Talab evini - Toxicology Research Center, Excellence Center of Clinical Toxicology AND Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mitra Rahimi - Shahid Beheshti University of Medical Sciences
Shahin Shadnia - Toxicology Research Center, Excellence Center of Clinical Toxicology AND Department of Clinical Toxicology, Loghman Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background: In acute and chronic phases of severe diseases, endocrine changes occur. Some hormones, such as prolactin (PRL) and thyroid hormones, were considered predictors of ICU patients' outcomes. The present study evaluates thyroid hormone profile, serum PRL level, and their relationship with ICU poisoned patients' mortality rate.Methods: This study included ۱۴۰ inpatients in the Toxicology Intensive Care Unit (TICU) who enrolled in a prospective study of a single center and observational. After admission to the ICU, the researchers collected venous blood samples from all patients directly. Concurrently, the APACHE II score was calculated. The collected samples analysis was performed based on the entire triiodothyronine (T۳), thyroxine (T۴), thyroid-stimulating hormone (TSH), and PRL level.Results: One hundred and forty subjects were studied, of which ۱۰۹ (۷۵.۸۵%) were male with a mean age of ۳۴.۱۷ ± ۱۴.۰۱. One hundred and eighteen patients were survivors with a mean age of ۳۳.۲۹ ±۱۳.۷۶. In contrast, ۲۲ patients with a mean age of ۳۸.۹۱ ±۱۴.۶۹ died. The model of PRL combined with APACHE II score (OR ۱.۱۷, ۹۵% CI ۱.۰۶ to ۱.۲۸, P-value =۰.۰۰۱) was the best model for predicting post-ICU mortality in our study.Conclusions: This study’s results are consistent with the previous research, indicating a higher incidence of thyroid and PRL hormone changes in patients hospitalized in the ICU.   It can be concluded that the presence of PRL based on the APACHE II score can lead us to be more precise in predicting the outcome of poisoning in hospitalized patients.

APACHE II score, Mortality, Prolactin, Thyroid hormones