Characterization of bacteriophages from wastewater sources on Streptococcus spp. isolated from biological samples

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 147

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شناسه ملی سند علمی:

MEDISM22_337

تاریخ نمایه سازی: 8 مهر 1400

چکیده مقاله:

Background and Aim : In recent decades, inappropriate and excessive use of antibiotics have resulted in frequent antimicrobial resistance in bacteria. This phenomenon has created several problems in treatment of bacterial infections, leading to increased case mortalities and treatment expenses. A good solution to solve the problem is use of bacteriophages in bacterial treatment as these bacterial viruses include zero or minimum side-effects. The aims of this study were to isolate and identify bacteriophages from biological samples.Methods : In this study, wastewater samples were used to characterize bacteriophages on streptococcal isolates from clinically isolated biological samples in Tehran, ۲۰۱۹–۲۰۲۰. Then, bacteriophages were comprehensively characterized using phenotypic and molecular methods.Results : Of all samples collected from the hospital, ۲۰ isolates belonged to viridans group and Group B streptococci. Overall, five bacteriophages were isolated from Streptococcus agalactiae strains with no host specificity since these bacteriophages lysed Enterococcus spp. as well.Conclusion : Since emergence of antibiotic-resistant bacteria has created numerous medical problems, characterization of bacteriophage to use in infection treatment seems a promising solution.

نویسندگان

Maryam Yazdanizad

Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Maryam Montazeri

Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

Ali Akbar Saboor Yaraghi

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Ramin Mazaheri Nezhad Fard

Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran