Association of antibiotic resistance patterns in clinical isolates of A. baumannii and frequency of biofilm formation
- سال انتشار: 1400
- محل انتشار: بیست دومین کنگره میکروب شناسی ایران (مجازی)
- کد COI اختصاصی: MEDISM22_333
- زبان مقاله: انگلیسی
- تعداد مشاهده: 217
نویسندگان
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Hossein Soroush Barhaghi
Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Background and Aim : Background: Acinetobacter baumannii due to high propensity of biofilms formation and high frequency of multi-drug resistant (MDR) is an important microorganism that causes nosocomial infections. Aim: The aim of this study was investigation of antibiotic resistance patterns in clinical isolates of A. baumannii and frequency of biofilm formation, and correlation between MDR and propensity of biofilms formation. Methods : Methods: One hundred A. baumannii isolates were collected from three University affiliated hospitals in Tabriz, Iran during ۲۰۱۵-۲۰۱۶. The antibiotic resistance patterns and in vitro biofilm-forming ability were evaluated by the disk diffusion and microtiter plate methods, respectivelyResults : Results: Eighty-eight A. baumannii isolates were MDR and have high resistant to cefepime, third generation cephalosporins, imipenem, ciprofloxacin, cotrimoxazole, amikacin, meropenem and gentamicin. Resistance to colistin was observed in ۴ isolates. Assessment of biofilm formation introduced ۷۵% of the isolates biofilm producer. A significant correlation was observed between the ability of biofilms formation and MDR strains.Conclusion : Conclusion: The results of this study indicate that high levels of drug resistance of clinical isolates of A. baumannii. The ability of biofilm formation in MDR isolates causing infection ability and stability of the organisms in the hospital environment. The results of this study highlight the importance of developing detailed programs to control infections caused by Acinetobacter baumannii in our hospitals.کلیدواژه ها
Acinetobacter baumannii, biofilms, Drug Resistanceمقالات مرتبط جدید
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