ptk۲ and mt۲a genes֝ expression in patients with Helicobacter pylori infection

Background and Aim : Many studies show that the Helicobacter pylori virulence factors determine the direction of the infection's clinical fate. Previous studies indicate ptk۲ and mt۲a gene products are located at both ends of the spectrum of cell destiny including proliferation and apoptosis, respectively. Methods : In this study by designing a case-control study involved gastric adenocarcinoma and gastritis patients with and without H. pylori infection, the correlations between ptk۲ and mt۲a genes֝ expression in gastric antral epithelial cells were surveyed. Results : The results showed the negative correlations between age and type of disease with ptk۲ gene ΔCt value (p<۰.۰۵). The presence of H. pylori iceA۱/۲ and cagE genes cDNA in gastric biopsy samples had positive and negative correlations with the ptk۲ gene ΔCt value (p<۰.۰۵).Conclusion : There was a weak correlation between the presence of H. pylori babA۲/B, oipA, and cagY genes cDNA in gastric biopsy samples and mt۲a gene ΔCt value (p<۰.۱).

کلیدواژه ها:

Helicobacter pylori ، ptk۲ gene ، mt۲a gene ، Virulence genes ، Gastric adenocarcinoma ، Gastritis