Investigation the effect of probiotics in the treatment of SARS-CoV-۲ (Systematic review)

Background and Aim : The coronavirus disease ۱۹ (COVID-۱۹) is a highly transmittable and pathogenic viral infection and real health challenge of the ۲۱st century for all human life worldwide. Probiotics can contribute to defense against potential pathogens by promoting effective immune interactions. So the aim of this study is investigating the effect of probiotics in the treatment of SARS-CoV-۲.Methods : This review article was performed within articles published at PubMed, Science direct, Google Scholar, SID and Cochrane until August ۲۰۲۱. The keywords were SARS-CoV-۲, probiotics and treatment. By searching this database; ۱۵۲ articles were found, ۷۴ of them by reading titles and abstracts were removed. ۷۸ articles were selected under the inclusion criteria. All articles chosen from English and Persian articles.Results : Finally, ۷۸ articles were included in the study. Probiotic actions such as IgA secretion stimulation to improve mucosal immunity, influence on cytokines production by intestinal epithelial cells, modulation of levels and function of regulatory cells, activation of phagocytosis and macrophage production, and induction of dendritic cells maturation, probably affected systemic inflammation. Adjunctive therapies based on the modulation of the gut-lung axis and re-establishment of eubiosis could be a significant therapeutic procedure for diminishing the harmful ramifications of COVID-۱۹. Lactobacillus contained a HSP۲۷-inducible polyphosphate fraction. Thus, probiotic-derived polyphosphates, escalated the epithelial barrier function and kept intestinal homeostasis through the integrin-p۳۸ MAPK pathway. Therefore, the role of probiotics-based therapy became substantial in the management of viral infections. Probiotics could modulate host immune responses and warded off the cytokine storm produced during COVID-۱۹ infection.Conclusion : It seems that probiotics have abundant benefits such as balancing the composition of human gut microflora, strengthening gut barrier function, and protective immune responses in COVID-۱۹ management. However, need to be more research done at this topic.

کلیدواژه ها:

Probiotics ، SARS-Cov-۲ ، COVID-۱۹ ، Treatment