A review of the Anti-inflammatory effects of Mentha pulegium as a possible candidate in the treatment of patients with COVID_۱۹

  • سال انتشار: 1400
  • محل انتشار: بیست دومین کنگره میکروب شناسی ایران (مجازی)
  • کد COI اختصاصی: MEDISM22_314
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 276
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نویسندگان

Sajjad Jafari

Member of the Student Research Committee, Urmia University of Medical Sciences. Urmia, IRAN, IRNA

Masooma Rahimzadea

Master of Hematology Immunology Dept. Ghaem Hospital, Medical school, Mashhad University of Medical Sciences, Mashhad, Iran, Iran

reyhane rasizade

Master student of virology, Tabriz University of Medical Sciences, Tabriz, Iran, Iran

چکیده

Background and Aim : One of the major complications in patients with Covid-۱۹ disease is cytokine storm, which is an abnormal immune response that leads to severe pneumonia. TNF-α, IFN-α are important secretory cytokines in this disease, both of which have a synergistic effect in inflammation, lung damage and mortality. Due to the lack of a suitable drug in the treatment of Covid-۱۹ disease, many studies have shown that plant extracts have a variety of biological effects such as immunomodulatory properties. the aim of this study was to review the Anti-inflammatory effects of Mentha pulegium as a possible candidate in the treatment of patients with COVID_۱۹.Methods : The present study is a review study by searching reputable scientific databases such as Pubmed Google scholar, Scopus from ۲۰۱۵ to ۲۰۲۱ using the keywords SARS-COV-۲, Covid-۱۹, TNF-α, IFN-γ, cytokine storm , Treatment, Anti-inflammatory Latest information obtained.Results : In this study, ۳۰ articles were reviewed, Therefore, Mentha pulegium plant has anti-inflammatory activity with effective compounds such as alkaloids, flavonoids, thymol and carvacrol. The results of these studies as invitro-invivo confirm the therapeutic effects of Mentha pulegium.Conclusion : Due to the widespread prevalence of Covid_۱۹ disease and secretion of TNF-α, IFN-γ, which can cause shock due to further spread of lung damage and subsequent pneumonia, acute respiratory distress syndrome, loss of respiratory control and other organs, and death. Therefore, a drug is needed to block and inhibit these cytokines. Due to having the mentioned active ingredients, oregano Mentha pulegium plant can be evaluated as a possible drug candidate in the treatment of patients with covid_۱۹ clinical trial.

کلیدواژه ها

Mentha pulegium, covid-۱۹, Anti-inflammatory,Treatment

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