Prevalence of COVID ۱۹ in the Brain-Dead Candidates for organ transplantation

سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 94

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شناسه ملی سند علمی:

MEDISM22_298

تاریخ نمایه سازی: 8 مهر 1400

چکیده مقاله:

Background and Aim : This study aimed to evaluate the prevalence of Coronavirus Disease ۲۰۱۹ (COVID-۱۹) positive cases meeting clinical brain death criteria; moreover, it was attempted to assess the uncommon manifestations of the infection in this study Methods : This retrospective observational study was conducted on all brain-dead patients who were referred to the emergency department of hospitals in Mashhad, Iran, from February to October ۲۰۲۰. The demographic characteristics, clinical information, and laboratory data were collected and recorded in a researcher-made checklist Results : The PCR test result was positive for COVID-۱۹ in ۵۴% of the patients, and syncope was reported in ۱۶.۱% of the cases (n=۱۰). Furthermore, the majority of the patients (۵۲.۹%) showed central nervous system (CNS) hemorrhagic manifestations. A comparison was made between the patients with positive and negative PCR test result in terms of syncope; accordingly, there was a significant difference between them in this regard (χ۲=۴.۵; P=۰.۰۳). The CNS hemorrhagic manifestations were significantly higher in patients with positive PCR, compared to those with negative PCR (χ۲=۴.۵۷, P=۰.۰۳). Moreover, the grand glass opacity and pleural effusion were the most common findings of the chest computed tomography in brain-dead patients with COVID-۱۹ Conclusion : Due to the high prevalence of COVID-۱۹ among brain-dead patients, it seems that syncope attack should be regarded as one of the possible symptoms of COVID-۱۹. Moreover, syncope as a result of COVID-۱۹ may itself cause traumatic events. It is worth mentioning that CNS hemorrhagic manifestations have been reported in more than half of the patients with brain death.

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نویسندگان

Rozita Khodashahi

Department of Infectious Diseases and Tropical Medicine, Faculty of Medicine,Mashhad University of Sciences, Mashhad, Iran

Mohsen Aliakbarian

Surgical Oncology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ebrahim Khaleghi

Organ Procurement & Transplant Center of Mashhad University of Medical Sciences, Montaserieh Hospital, Mashhad, Iran