Ibuprofen and SARS-CoV-۲ infection are synergistic on cell death
- سال انتشار: 1400
- محل انتشار: بیست دومین کنگره میکروب شناسی ایران (مجازی)
- کد COI اختصاصی: MEDISM22_295
- زبان مقاله: انگلیسی
- تعداد مشاهده: 182
نویسندگان
Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. ۲. Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. ۲. Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
چکیده
Background and Aim : coronavirus disease ۲۰۱۹ (COVID-۱۹) has created a growing alarm due to lack of chemotherapy and global strategy for eradication. Many speculations have been put forth about strategies, prevention, and therapy of this new coronavirus infection. One was from the University Clinic of Vienna on the possibility of synergism between RNA replication of severe acute respiratory syndrome coronavirus-۲ (SARS-CoV-۲) and consumption of ibuprofen in patients with high frequency of death (data not published to date). It means ibuprofen would have parallel effects with SARS-CoV-۲ on the death of patients. What are the scientific reasons? Methods : Let’s look at the brief description in the field of interaction between ibuprofen and antiviral cell system. We know that ibuprofen, as a nonsteroidal anti-inflammatory drug (NSAID), inhibits activity of Cox۱ and Cox۲ enzymes . Cox۱ and Cox۲ enzymes can catalyze arachidonic acid to prostaglandin after some intermediate substrates . Prostaglandins such as PGE۲ and PGI۲ play a role within the immune system toward protection against infection Results : So consumption of NSAIDs such as ibuprofen in patients with COVID-۱۹ can lead to intervention in cell defense mechanisms . In addition, ibuprofen is a scavenger of nitrogen radicals Conclusion : A previous study has indicated an antagonistic effect of ibuprofen on nitric oxide synthetase isoforms . More studies are needed, but it seems that a decrease of nitrogen radicals in infected cells with SARS-CoV-۲ can lead to an increase of viral RNA load in cells.کلیدواژه ها
Ibuprofen, SARS-CoV-۲, COVID-۱۹, nitrogen radicals, immune system, anti-inflammatoryمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.