Angiotensin (۱-۷) levels and disease severity in hospitalized COVID-۱۹ patients with and without cardiovascular diseases
محل انتشار: بیست دومین کنگره میکروب شناسی ایران (مجازی)
سال انتشار: 1400
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 247
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شناسه ملی سند علمی:
MEDISM22_203
تاریخ نمایه سازی: 8 مهر 1400
چکیده مقاله:
Background and Aim : Angiotensin (۱-۷) (Ang (۱-۷)) obtained from the function of angiotensin-converting enzyme ۲ (AEC۲) improve heart and lung function. Blockade of ACE۲ by severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) in coronavirus disease ۲۰۱۹ (COVID-۱۹) decreases Ang (۱-۷). In this study, we investigated Ang (۱-۷) levels and disease severity in hospitalized COVID-۱۹ patients with and without cardiovascular diseasesMethods : To do so, the Ang (۱-۷) levels of hospitalized COVID-۱۹ patients with (۱۳۶) and without (۱۲۷) cardiovascular disease in Masih-Daneshvari Hospital, Tehran, Iran were measured by ELIZA kit. , the patients’ clinical symptoms, including intensive care unit (ICU) admission, the use of mechanical ventilation, oxygen need, fever, and gastrointestinal disorders were drawing out from the patient's medical record.Results : Results of our investigation showed a significant inverse relationship between the levels of Ang ۱-۷ and the severity of the disease (P value = ۰.۰۰۰). But there wasn’t significant difference between the levels of Ang ۱-۷ in hospitalized COVID-۱۹ patients with and without cardiovascular diseases.Conclusion : Ang (۱-۷) reduced the severity of COVID-۱۹ disease, both in patients with and without cardiovascular
کلیدواژه ها:
Angiotensin (۱-۷) ، angiotensin-converting enzyme ۲ ، severe acute respiratory syndrome coronavirus ۲
نویسندگان
Fatemeh Imanparast
Infectious Diseases Research Center (IDRC), Arak University of medical sciences, Arak, Iran
Seyed Mohammad Seyedmehdi
Dr. Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.