Rare Actinobacteria and Their Biotechnological Potential Applications

Background and Aim : The increasing prevalence of nosocomial infections, due to the arbitrary use of antibiotics, has caused serious health problems. Natural compounds have been used for many years to treat and cure many infections. Rare actinobacteria are one of the main sources for the discovery and isolation of natural compounds with pharmaceutical properties. The main purpose of this review article is to study new metabolites derived from rare actinobacteria, and to evaluate their medicinal and pharmaceutical applications.Methods : This review includes over ۱۸۳ quality peer-reviewed papers available in the databases of Scopus, PubMed, Web of Science and ScienceDirect from ۲۰۱۵ to ۲۰۲۱.Results : This study presents the chemical structure of ۱۱۳ new isolated compounds from rare actinobacteria and their biological activity. This study also shows that rare actinobacteria have the ability to produce a variety of biologically active compounds such as alkaloids, flavonoids, terpenes and polyketides with a diverse range of biological activities including antibacterial, antifungal, antiviral and anticancer properties. Conclusion : The results of this study revealed that rare actinobacteria are an excellent source for the production of natural active compounds with high therapeutic and applied potentials in medical, pharmaceutical and agricultural biotechnology. It also highlights the key role of these compounds in the development of drugs needed by humans in the near future.

کلیدواژه ها:

Actinobacteria ، chemical composition ، chemical properties ، anti-bacterial ، anti-cancer ، anti-fungal