Distribution and antibiotic susceptibility pattern of Hypervirulent Klebsiella pneumoniae (HvKp) strains isolated from hospitalized patients in North of Iran
- سال انتشار: 1400
- محل انتشار: بیست دومین کنگره میکروب شناسی ایران (مجازی)
- کد COI اختصاصی: MEDISM22_135
- زبان مقاله: انگلیسی
- تعداد مشاهده: 534
نویسندگان
Mohammad Hossein Tayefeh Arbab
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
Infectious Diseases and Tropical Medicine Research Center, Babol University of Medical Sciences, Babol, Iran
چکیده
Background and Aim : Hypervirulent Klebsiella pneumoniae (hvKp) is an increasingly recognized pathotype of K. pneumoniae characterized clinically by its ability to cause organ- or life-threatening infections in healthy hosts from the community. One of the concerns of physicians and health communities about the recent pathogen is the emergence of multidrug resistance (MDR) and Extended-Spectrum β-Lactamase (ESBL) phentotype. Therefore, the aim of this study is to isolation, identification and determination of antibiotic susceptibility pattern of HvKp strains isolated from hospitalized patients in North of IranMethods : In this study, ۹۰ clinical samples of K. pneumoniae were collected randomly from three teaching hospitals affiliated to Babol University of Medical Sciences in the form of microbial plates. Stringent tests were used to identify HVKP strains. In this study, K. pneumoniae ATCC ۱۳۸۸۳ and Escherichia coli ATCC۲۵۹۲۲ were used as positive and negative control, respectively. Antibiotic susceptibility of HvKp isolates was determined according to CLSI standards. Antibiotics used in disk diffusion test include ciprofloxacin, amikacin, trimethoprim /sulfamethoxazole, cefotaxime, ampicillin, aztreonam, imipenem, tetracycline, gentamicin, ceftazidime and cefepime. Finally, multiple resistance phenotypes (MDR) were identified.Results : From ۹۰ clinical samples of K. pneumoniae, ۴۰ isolates of HvKp strains were isolated according to specific tests. According to susceptibility test, the highest resistance rate was observed against ampicillin (۱۰۰%) followed by trimethoprim /sulfamethoxazole (۶۷/۷%), cefotaxime (۵۶/۶%), ceftazidime (۵۲/۲%), aztreonam (۴۷/۷%), tetracycline (۴۴/۴%), gentamicin (۴۳/۳%), cefepime (۳۶/۶%), amikacin (۳۵/۵%), ciprofloxacin (۲۵/۵%) and imipenem (۱۲/۲%). Moreover, all isolates were MDR.Conclusion : HvKp, especially ESBL-hvKp and MDR-hvKp, is emerging in the hospitalized patients. It is essential to enhance clinical awareness and management of hvKp infections.کلیدواژه ها
Klebsiella pneumoniae; Antibiotic resistance ; Hypervirulent; HvKpمقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.